Title : Peroxisome proliferator-activated receptor α activation induces hepatic steatosis, suggesting an adverse effect.

Pub. Date : 2014

PMID : 24926685






4 Functional Relationships(s)
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1 Although fibrates activate peroxisome proliferator-activated receptor alpha (PPARalpha), leading to the reduction of serum triglyceride levels, the effects of these drugs on NAFLD remain controversial. Triglycerides peroxisome proliferator activated receptor alpha Mus musculus
2 Although fibrates activate peroxisome proliferator-activated receptor alpha (PPARalpha), leading to the reduction of serum triglyceride levels, the effects of these drugs on NAFLD remain controversial. Triglycerides peroxisome proliferator activated receptor alpha Mus musculus
3 In the present study, we focused on exploring the effect and mechanism of PPARalpha activation on hepatic triglyceride accumulation and hepatic steatosis. Triglycerides peroxisome proliferator activated receptor alpha Mus musculus
4 Taken together, these findings indicate the molecular mechanism by which PPARalpha activation increases liver triglyceride accumulation and suggest an adverse effect of fibrates on the pathogenesis of hepatic steatosis. Triglycerides peroxisome proliferator activated receptor alpha Mus musculus