Pub. Date : 2014 Aug
PMID : 24917395
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It metabolizes PGD2 to 9alpha11beta-PGF2 , diverting the spontaneous conversion of PGD2 to the PPARgamma agonist, 15-Deoxy-Delta-12, 14-prostaglandin J2 (15d-PGJ2 ). | 15-deoxy-delta(12,14)-prostaglandin J2 | peroxisome proliferator activated receptor gamma | Mus musculus |
| 2 | It metabolizes PGD2 to 9alpha11beta-PGF2 , diverting the spontaneous conversion of PGD2 to the PPARgamma agonist, 15-Deoxy-Delta-12, 14-prostaglandin J2 (15d-PGJ2 ). | 15-deoxy-delta(12,14)-prostaglandin J2 | peroxisome proliferator activated receptor gamma | Mus musculus |
| 3 | Although attenuating AKR1C3 expression in SCC cells by siRNA did not affect growth, treatment with PGD2 and its dehydration metabolite, 15d-PGJ2 , decreased SCC proliferation in a PPARgamma-dependent manner. | 15-deoxy-delta(12,14)-prostaglandin J2 | peroxisome proliferator activated receptor gamma | Mus musculus |
| 4 | This work suggests that PGD2 and its metabolite 15d-PGJ2 attenuate SCC proliferation in a PPARgamma-dependent manner, therefore activation of PPARgamma by agonists such as pioglitazone may benefit those at high risk of SCC. | 15-deoxy-delta(12,14)-prostaglandin J2 | peroxisome proliferator activated receptor gamma | Mus musculus |
| 5 | This work suggests that PGD2 and its metabolite 15d-PGJ2 attenuate SCC proliferation in a PPARgamma-dependent manner, therefore activation of PPARgamma by agonists such as pioglitazone may benefit those at high risk of SCC. | 15-deoxy-delta(12,14)-prostaglandin J2 | peroxisome proliferator activated receptor gamma | Mus musculus |