Title : 'Clickable' 2,5-diketopiperazines as scaffolds for ligation of biomolecules: their use in Aβ inhibitor assembly.

Pub. Date : 2014 Jul 21

PMID : 24879532






1 Functional Relationships(s)
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1 The orthogonally Boc/Alloc protected DKP precursors prepared from L-lysine residues and an aminohexyl arm are efficiently prepared on a gram scale by sequentially using Fukuyama-Mitsunobu alkylation, dipeptide coupling and diketopiperazine ring formation as key steps. Dipeptides BOC cell adhesion associated, oncogene regulated Homo sapiens