Title : Structural and biochemical characterization of the folyl-poly-γ-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II.

Pub. Date : 2014 Jul

PMID : 24863754






8 Functional Relationships(s)
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1 In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ). Folic Acid folate hydrolase 1 Homo sapiens
2 In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ). Folic Acid folate hydrolase 1 Homo sapiens
3 In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ). Folic Acid folate hydrolase 1 Homo sapiens
4 In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ). Folic Acid folate hydrolase 1 Homo sapiens
5 In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ). Folic Acid folate hydrolase 1 Homo sapiens
6 In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ). Folic Acid folate hydrolase 1 Homo sapiens
7 As a result, the crystallographic data reveal considerable details about the binding mode of polyglutamylated folates to GCPII, especially the engagement of the arene binding site in recognizing the folic acid moiety. Folic Acid folate hydrolase 1 Homo sapiens
8 As a result, the crystallographic data reveal considerable details about the binding mode of polyglutamylated folates to GCPII, especially the engagement of the arene binding site in recognizing the folic acid moiety. Folic Acid folate hydrolase 1 Homo sapiens