Title : Ultrasmall gold nanoparticles as carriers for nucleus-based gene therapy due to size-dependent nuclear entry.

Pub. Date : 2014 Jun 24

PMID : 24824865






5 Functional Relationships(s)
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1 We then investigated the possibility of using ultrasmall 2 nm nanoparticles as carriers for nuclear delivery of a triplex-forming oligonucleotide (TFO) that binds to the c-myc promoter. tfo MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 Compared to free TFO, the nanoparticle-conjugated TFO was more effective at reducing c-myc RNA and c-myc protein, which resulted in reduced cell viability. tfo MYC proto-oncogene, bHLH transcription factor Homo sapiens
3 Compared to free TFO, the nanoparticle-conjugated TFO was more effective at reducing c-myc RNA and c-myc protein, which resulted in reduced cell viability. tfo MYC proto-oncogene, bHLH transcription factor Homo sapiens
4 Compared to free TFO, the nanoparticle-conjugated TFO was more effective at reducing c-myc RNA and c-myc protein, which resulted in reduced cell viability. tfo MYC proto-oncogene, bHLH transcription factor Homo sapiens
5 Compared to free TFO, the nanoparticle-conjugated TFO was more effective at reducing c-myc RNA and c-myc protein, which resulted in reduced cell viability. tfo MYC proto-oncogene, bHLH transcription factor Homo sapiens