Title : Localization of the inhibitory site(s) of pentosan polysulphate in blood coagulation.

Pub. Date : 1988 Oct 31

PMID : 2464199






3 Functional Relationships(s)
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1 In contrast to a current hypothesis the antithrombin III independent effect of PPS on blood coagulation is not caused by preventing the binding of the factors IX, IXa, X, Xa, VIII, V, Va and II onto procoagulant phospholipids. Pentosan Sulfuric Polyester serpin family C member 1 Homo sapiens
2 We postulate therefore that the antithrombin III independent inhibitory effect of PPS on thrombin generation on blood coagulation is by interaction with factor VIIIa. Pentosan Sulfuric Polyester serpin family C member 1 Homo sapiens
3 This effect is additional to the heparin-like action of PPS, i.e. potentiation of the activity of antithrombin III and/or heparin cofactor II. Pentosan Sulfuric Polyester serpin family C member 1 Homo sapiens