Title : Gastric cytoprotection by prostaglandin E₂ and prostacyclin: relationship to EP1 and IP receptors.

Pub. Date : 2014 Feb

PMID : 24622825






4 Functional Relationships(s)
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Protein Name
Organism
1 Gastric cytoprotection by prostaglandin E2 and prostacyclin: relationship to EP1 and IP receptors. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
2 The effects of PGE2 on various gastric functions are mediated by different EP receptor subtypes; inhibition of acid secretion (EP3) and motility (EP1), stimulation of mucus secretion (EP4) and HCO3- secretion (EP1), and an increase in mucosal blood flow (EP2/EP4). Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
3 The effects of PGE2 on various gastric functions are mediated by different EP receptor subtypes; inhibition of acid secretion (EP3) and motility (EP1), stimulation of mucus secretion (EP4) and HCO3- secretion (EP1), and an increase in mucosal blood flow (EP2/EP4). Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
4 In conclusion, the presence of EP1 receptors is essential to the protective action of PGE2, either generated endogenously or administered exogenously, against HCl/ ethanol or indomethacin, and this action is functionally associated with the inhibition of gastric motility. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus