Title : Acute wounding alters the beta2-adrenergic signaling and catecholamine synthetic pathways in keratinocytes.

Pub. Date : 2014 Aug

PMID : 24614156






3 Functional Relationships(s)
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1 Norepinephrine impaired keratinocyte migration; this effect was abrogated with B2AR-selective antagonist ICI-118,551 but not with B1AR-selective antagonist bisoprolol. Norepinephrine adrenoceptor beta 2 Homo sapiens
2 Finally, for clinical relevance, we determined that norepinephrine was present in freshly wounded skin, thus providing a potential mechanism for impaired healing by local B2AR activation in wound-edge keratinocytes. Norepinephrine adrenoceptor beta 2 Homo sapiens
3 Norepinephrine appears to be a stress-related mediator that impairs keratinocyte migration through activation of the B2AR. Norepinephrine adrenoceptor beta 2 Homo sapiens