Pub. Date : 2014 Jun
PMID : 24612036
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The challenge of differentiated SK-N-BE human neuroblastoma cells with patho-physiologically relevant amounts of 27-OH and 24-OH showed that both oxysterols induce a net synthesis of Abeta1-42 by up-regulating expression levels of amyloid precursor protein and beta-secretase, as well as the beta-secretase activity. | Oxysterols | amyloid beta precursor protein | Homo sapiens |
| 2 | The reported findings link an impaired cholesterol oxidative metabolism to an excessive beta-amyloidogenesis and point to NAC as an efficient inhibitor of oxysterols-induced Abeta toxic peptide accumulation in the brain. | Oxysterols | amyloid beta precursor protein | Homo sapiens |