Title : Tributyltin affects adipogenic cell fate commitment in mesenchymal stem cells by a PPARĪ³ independent mechanism.

Pub. Date : 2014 May 5

PMID : 24513447






4 Functional Relationships(s)
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1 Although prenatal TBT exposure has been shown to induce obesity, the underlying mechanisms and the role of the transcription factor PPARgamma are not clarified yet. tributyltin peroxisome proliferator activated receptor gamma Mus musculus
2 Depending on the exposure window, TBT promoted subsequent adipogenesis independently and dependently from PPARgamma. tributyltin peroxisome proliferator activated receptor gamma Mus musculus
3 In undifferentiated MSC, TBT exposure induced a transcriptional PPARgamma-independent repression of Pref-1 and SOX9, which are both suppressors of adipogenic cell fate commitment. tributyltin peroxisome proliferator activated receptor gamma Mus musculus
4 During hormonal induction TBT additionally enhanced adipogenic differentiation by PPARgamma signaling. tributyltin peroxisome proliferator activated receptor gamma Mus musculus