Title : Sulindac compounds facilitate the cytotoxicity of β-lapachone by up-regulation of NAD(P)H quinone oxidoreductase in human lung cancer cells.

Pub. Date : 2014

PMID : 24505400






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1 In conclusion, sulindac and its metabolites synergistically increase the anticancer effects of beta-lapachone primarily by increasing NQO1 activity and expression, and these two drugs may provide a novel combination therapy for lung cancers. Sulindac NAD(P)H quinone dehydrogenase 1 Homo sapiens