Title : Human steroid and oxysterol 7α-hydroxylase CYP7B1: substrate specificity, azole binding and misfolding of clinically relevant mutants.

Pub. Date : 2014 Mar

PMID : 24491228






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CYP7B1 catalyzes the 6- or 7-hydroxylation of both steroids and oxysterols and thus is involved in the metabolism of neurosteroids and bile acid synthesis, respectively. Oxysterols cytochrome P450 family 7 subfamily B member 1 Homo sapiens
2 Metabolic conversion (deactivation) of oxysterols by CYP7B1 in a reconstituted system proceeds via two sequential hydroxylations. Oxysterols cytochrome P450 family 7 subfamily B member 1 Homo sapiens