Title : Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations.

Pub. Date : 2014

PMID : 24477114






1 Functional Relationships(s)
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1 We observe substantial and differential effects upon amide-to-ester mutation in PDZ2 of postsynaptic density protein 95 and other PDZ domains, suggesting that hydrogen bonding at the carboxylate-binding site contributes to both affinity and selectivity. Esters discs large MAGUK scaffold protein 4 Homo sapiens