Title : In vivo imaging of cerebral dopamine D3 receptors in alcoholism.

Pub. Date : 2014 Jun

PMID : 24469594






3 Functional Relationships(s)
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1 Animal studies support the role of the dopamine D3 receptor (DRD3) in alcohol reinforcement or liking. Alcohols dopamine receptor D3 Homo sapiens
2 However, baseline [(11)C]PHNO binding was higher in alcohol-dependent patients in hypothalamus (VT: 16.5 +- 4 vs 13.7 +- 2.9, p = 0.040), a region in which the [(11)C]PHNO signal almost entirely reflects DRD3 availability. Alcohols dopamine receptor D3 Homo sapiens
3 Although we found no difference between alcohol-dependent patients and controls in striatal DRD3 levels, increased DRD3 binding in the hypothalamus of alcohol-dependent patients was observed. Alcohols dopamine receptor D3 Homo sapiens