Title : Arsenic trioxide induces apoptosis in human platelets via C-Jun NH2-terminal kinase activation.

Pub. Date : 2014

PMID : 24466103






1 Functional Relationships(s)
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1 Here we show that ATO dose-dependently induces depolarization of mitochondrial inner transmembrane potential (DeltaPsim), up-regulation of Bax and down-regulation of Bcl-2 and Bcl-XL, caspase-3 activation, and phosphotidylserine (PS) exposure in platelets. Arsenic Trioxide caspase 3 Homo sapiens