Title : Kinetics of the inflammatory response induced by free fatty acid accumulation in hepatocytes.

Pub. Date : 2013 Jan-2014 Feb

PMID : 24378274






2 Functional Relationships(s)
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1 A time- and dose-dependent upregulation of the expression of IL-6 and IL-8 mRNA was observed during the treatment at 3 and 24 h. In contrast, TNF-alpha mRNA expression was highly upregulated at 3 h after FFA exposure but returned to control values at 24 h. In conclusion, hepatocytes exposed in vitro for a short time to low FFA concentrations showed a significant upregulation of IL-6 and IL-8 to,and a rapid but transitory elevation of TNF-alpha. Fatty Acids, Nonesterified interleukin 6 Homo sapiens
2 A time- and dose-dependent upregulation of the expression of IL-6 and IL-8 mRNA was observed during the treatment at 3 and 24 h. In contrast, TNF-alpha mRNA expression was highly upregulated at 3 h after FFA exposure but returned to control values at 24 h. In conclusion, hepatocytes exposed in vitro for a short time to low FFA concentrations showed a significant upregulation of IL-6 and IL-8 to,and a rapid but transitory elevation of TNF-alpha. Fatty Acids, Nonesterified interleukin 6 Homo sapiens