Title : Role of PGE2 in the colonic motility: PGE2 generates and enhances spontaneous contractions of longitudinal smooth muscle in the rat colon.

Pub. Date : 2014 Mar

PMID : 24170253






2 Functional Relationships(s)
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1 In the presence of piroxicam, exogenous PGE2, both ONO-AE-248 (EP3 agonist), and ONO-DI-004 (EP1 agonist) induced GC-like contractions, and increased the frequency and amplitude. Dinoprostone prostaglandin E receptor 3 Rattus norvegicus
2 These results suggest that the endogenous PGE2 spontaneously generates and enhances the frequent phasic contractions directly activating the EP1 and EP3 receptors expressed on longitudinal smooth muscle cells in the rat middle colon. Dinoprostone prostaglandin E receptor 3 Rattus norvegicus