Title : STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor.

Pub. Date : 2013 Oct 15

PMID : 24082147






1 Functional Relationships(s)
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Protein Name
Organism
1 SOCS3, the major negative regulator of STAT3, is induced by tyrosine-phosphorylated STAT3 and terminates STAT3 phosphorylation about 2 h after initial exposure of cells to members of the IL-6 family of cytokines by binding cooperatively to the common receptor subunit gp130 and JAKs 1 and 2. Tyrosine Janus kinase 1 Homo sapiens