Pub. Date : 2013 Sep 24
PMID : 23977830
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | While in vitro or in vivo eNOS S-glutathionylation with modification of Cys689 and Cys908 of its reductase domain is triggered by high levels of glutathione disulfide (GSSG) or oxidative thiyl radical formation, it remains unclear how this process may be reversed. | Glutathione Disulfide | nitric oxide synthase 3 | Homo sapiens |
| 2 | While in vitro or in vivo eNOS S-glutathionylation with modification of Cys689 and Cys908 of its reductase domain is triggered by high levels of glutathione disulfide (GSSG) or oxidative thiyl radical formation, it remains unclear how this process may be reversed. | Glutathione Disulfide | nitric oxide synthase 3 | Homo sapiens |
| 3 | Because Grx1 also catalyzes protein S-glutathionylation with an increased [GSSG]/[GSH] ratio, we measured its effect on eNOS S-glutathionylation when the [GSSG]/[GSH] ratio was >0.2, which can occur in cells and tissues under oxidative stress, and observed an increased level of eNOS S-glutathionylation with a marked decrease in eNOS activity without uncoupling. | Glutathione Disulfide | nitric oxide synthase 3 | Homo sapiens |
| 4 | This eNOS S-glutathionylation was reversed with a decrease in the [GSSG]/[GSH] ratio to <0.1. | Glutathione Disulfide | nitric oxide synthase 3 | Homo sapiens |