Title : Salmonella require the fatty acid regulator PPARĪ“ for the establishment of a metabolic environment essential for long-term persistence.

Pub. Date : 2013 Aug 14

PMID : 23954156






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PPARdelta deficiency dramatically inhibits Salmonella replication, which is linked to the metabolic state of macrophages and the level of intracellular glucose available to bacteria. Glucose peroxisome proliferator activator receptor delta Mus musculus
2 Pharmacological activation of PPARdelta increases glucose availability and enhances bacterial replication in macrophages and mice, while Salmonella fail to persist in Ppardelta null mice. Glucose peroxisome proliferator activator receptor delta Mus musculus