Title : Pioglitazone does not improve insulin signaling in mice with GH over-expression.

Pub. Date : 2013 Nov

PMID : 23946430






1 Functional Relationships(s)
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Protein Name
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1 In the liver, PIO decreased the phosphorylation of insulin receptor substrate-1 (IRS1) at a serine residue (Ser(307)-pS-IRS1), which inhibits insulin action, and had a tendency to increase tyrosine phosphorylation of IRS2 (Tyr-pY-IRS2) only in N mice but did not affect either of these parameters in Tg mice. Tyrosine insulin receptor substrate 1 Mus musculus