Title : Activation of GSK-3β and caspase-3 occurs in Nigral dopamine neurons during the development of apoptosis activated by a striatal injection of 6-hydroxydopamine.

Pub. Date : 2013

PMID : 23940672






3 Functional Relationships(s)
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1 Activation of GSK-3beta and caspase-3 occurs in Nigral dopamine neurons during the development of apoptosis activated by a striatal injection of 6-hydroxydopamine. Oxidopamine caspase 3 Homo sapiens
2 This work evaluated whether a single striatal injection of 6-OHDA causes progressive apoptosis of dopamine (DA) neurons and activation of glycogen synthase kinase 3beta (GSK-3beta) and caspase-3 in the substantia nigra compacta (SNc). Oxidopamine caspase 3 Homo sapiens
3 Our results suggest that caspase-3 and GSK-3beta pY216 activation might participate in the DA cell death and that the active caspase-3 might also participate in the neuroinflammation caused by the striatal 6-OHDA injection. Oxidopamine caspase 3 Homo sapiens