Title : Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation.

Pub. Date : 2013 Dec

PMID : 23916134






4 Functional Relationships(s)
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1 Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation. Nelfinavir mechanistic target of rapamycin kinase Homo sapiens
2 In this study, the treatment of cancer cells with ER stress-inducing drug nelfinavir resulted in the expression of endogenous mTOR inhibitor sestrin-2 (SESN2). Nelfinavir mechanistic target of rapamycin kinase Homo sapiens
3 Accordingly, cancer cells treated with the ER stress-inducing agent nelfinavir showed reduced mTOR activity and associated increases in the expression levels of ATF4 and SESN2. Nelfinavir mechanistic target of rapamycin kinase Homo sapiens
4 mTOR inhibition by nelfinavir, which is currently in clinical trials for cancer patients, may also explain its observed ability to induce autophagy, growth arrest, and radiosensitization in cancer cells. Nelfinavir mechanistic target of rapamycin kinase Homo sapiens