Title : PPAR╬▓/╬┤ modulates ethanol-induced hepatic effects by decreasing pyridoxal kinase activity.

Pub. Date : 2013 Sep 15

PMID : 23851158






3 Functional Relationships(s)
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1 PPARbeta/delta modulates ethanol-induced hepatic effects by decreasing pyridoxal kinase activity. Ethanol peroxisome proliferator activator receptor delta Mus musculus
2 Ethanol fed Pparbeta/delta-null mice exhibited steatosis after short-term treatment compared to controls, the latter effect appeared to be due to increased activity of sterol regulatory element binding protein 1c (SREBP1c). Ethanol peroxisome proliferator activator receptor delta Mus musculus
3 These data collectively suggest that PPARbeta/delta prevents ethanol-induced hepatic effects by inhibiting hepatic lipogenesis, modulation of amino acid metabolism, and altering pyridoxal kinase activity. Ethanol peroxisome proliferator activator receptor delta Mus musculus