Pub. Date : 2013 Sep 15
PMID : 23851158
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PPARbeta/delta modulates ethanol-induced hepatic effects by decreasing pyridoxal kinase activity. | Ethanol | peroxisome proliferator activator receptor delta | Mus musculus |
| 2 | Ethanol fed Pparbeta/delta-null mice exhibited steatosis after short-term treatment compared to controls, the latter effect appeared to be due to increased activity of sterol regulatory element binding protein 1c (SREBP1c). | Ethanol | peroxisome proliferator activator receptor delta | Mus musculus |
| 3 | These data collectively suggest that PPARbeta/delta prevents ethanol-induced hepatic effects by inhibiting hepatic lipogenesis, modulation of amino acid metabolism, and altering pyridoxal kinase activity. | Ethanol | peroxisome proliferator activator receptor delta | Mus musculus |