Title : Modulation of Rho-Rock signaling pathway protects oligodendrocytes against cytokine toxicity via PPAR-α-dependent mechanism.

Pub. Date : 2013 Sep

PMID : 23839981






3 Functional Relationships(s)
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1 In addition, the expression of ROS detoxifying enzymes (catalase and superoxide-dismutase 2) and the transactivation of peroxisome proliferators-activated receptor (PPAR)-alpha/-beta/-gamma including PPAR-gamma coactivator-1alpha were enhanced by LOV in similarly treated OLs. Reactive Oxygen Species peroxisome proliferator activated receptor alpha Mus musculus
2 In addition, the expression of ROS detoxifying enzymes (catalase and superoxide-dismutase 2) and the transactivation of peroxisome proliferators-activated receptor (PPAR)-alpha/-beta/-gamma including PPAR-gamma coactivator-1alpha were enhanced by LOV in similarly treated OLs. Reactive Oxygen Species peroxisome proliferator activated receptor alpha Mus musculus
3 Collectively, these data provide unprecedented evidence that LOV-mediated inhibition of the Rho-ROCK signaling pathway boosts ROS detoxifying defense in OLs via PPAR-alpha-dependent mechanism that has implication in neurodegenerative disorders including MS. Reactive Oxygen Species peroxisome proliferator activated receptor alpha Mus musculus