Title : A c-Myc activation sensor-based high-throughput drug screening identifies an antineoplastic effect of nitazoxanide.

Pub. Date : 2013 Sep

PMID : 23825064






4 Functional Relationships(s)
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1 A c-Myc activation sensor-based high-throughput drug screening identifies an antineoplastic effect of nitazoxanide. nitazoxanide MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 Validation of nitazoxanide in different cancer cell lines revealed a high potency for c-Myc inhibition with IC50 ranging between 10 and 500 nmol/L. nitazoxanide MYC proto-oncogene, bHLH transcription factor Homo sapiens
3 Oral administration of nitazoxanide in breast cancer xenograft mouse models significantly suppressed tumor growth by inhibition of c-Myc and induction of apoptosis. nitazoxanide MYC proto-oncogene, bHLH transcription factor Homo sapiens
4 These findings suggest a potential of nitazoxanide to be repurposed as a new antitumor agent for inhibition of c-Myc-associated neoplasia. nitazoxanide MYC proto-oncogene, bHLH transcription factor Homo sapiens