Pub. Date : 2013 Nov
PMID : 23800382
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of oxysterols on the interaction of Alzheimer"s amyloid beta with model membranes. | Oxysterols | amyloid beta precursor protein | Homo sapiens |
| 2 | However, the effect of cholesterol and its oxidized derivatives, oxysterols, on Abeta-induced neurotoxicity to membranes is not fully understood. | Oxysterols | amyloid beta precursor protein | Homo sapiens |
| 3 | Our results have indicated that oxysterols rendered membranes more sensitive to Abeta, in contrast to role of cholesterol in inhibiting Abeta/membrane interaction. | Oxysterols | amyloid beta precursor protein | Homo sapiens |
| 4 | These findings suggest the enhancing effect of oxysterols on interaction of Abeta with membranes and contribute to clarify the harmful impact of cholesterol on Abeta-induced neurotoxicity by means of its oxidation. | Oxysterols | amyloid beta precursor protein | Homo sapiens |