Title : [Expressions of reactive oxygen species and fibronectin are regulated by transcriptional co-activator p300 in human mesangial cells exposed to high glucose and methylglyoxal advanced glycation end products].

Pub. Date : 2013 Apr

PMID : 23643164






1 Functional Relationships(s)
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1 OBJECTIVE: To study the roles and interrelationship of transcriptional co-activator p300 and protein kinase Cbeta2(PKCbeta2) in the production of reactive oxygen species (ROS) and the expression of fibronectin in human mesangial cells (HMCs) under the stimulation of high glucose and methylglyoxal-derived advanced glycation end products (AGEs). Pyruvaldehyde E1A binding protein p300 Homo sapiens