Title : TCDD induces the expression of insulin-like growth factor binding protein 4 in 5L rat hepatoma cells: a cautionary tale of the use of this cell line in studies on dioxin toxicity.

Pub. Date : 2013 Jul 5

PMID : 23639626






1 Functional Relationships(s)
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1 By "working upwards" from mTOR, we observed that TCDD inhibited endogenous and IGF-I-induced AKT and ERK activation by interfering with tyrosine phosphorylation of insulin receptor substrate 1. Tyrosine insulin receptor substrate 1 Rattus norvegicus