Title : Role of hypoxia-inducible factor 1, α subunit and cAMP-response element binding protein 1 in synergistic release of interleukin 8 by prostaglandin E2 and nickel in lung fibroblasts.

Pub. Date : 2013 Jul

PMID : 23526216






4 Functional Relationships(s)
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1 Role of hypoxia-inducible factor 1, alpha subunit and cAMP-response element binding protein 1 in synergistic release of interleukin 8 by prostaglandin E2 and nickel in lung fibroblasts. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
2 The current study sought to identify the molecular events underlying Ni-induced alterations in PGE2 signaling and its effects on IL-8 production. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
3 PGE2 synergistically enhances Ni-induced IL-8 release from HLF in a concentration-dependent manner. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
4 PGE2 and forskolin stimulated cAMP, but it was only in the presence of Ni-induced hypoxia-inducible factor 1, alpha subunit (HIF1A) that these agents stimulated IL-8 release. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens