Title : CDK1 interacts with RARĪ³ and plays an important role in treatment response of acute myeloid leukemia.

Pub. Date : 2013 Apr 15

PMID : 23518499






6 Functional Relationships(s)
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Protein Name
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1 We showed that CDK1 function is required for all-trans retinoic acid (ATRA) to achieve the optimal effect in U-937 human leukemic cells. Tretinoin cyclin dependent kinase 1 Homo sapiens
2 We showed that CDK1 function is required for all-trans retinoic acid (ATRA) to achieve the optimal effect in U-937 human leukemic cells. Tretinoin cyclin dependent kinase 1 Homo sapiens
3 CDK1 modulates the levels of P27(kip) and AKT phosphorylation in response to ATRA treatment. Tretinoin cyclin dependent kinase 1 Homo sapiens
4 The regulation of the subcellular content of CDK1 and RARgamma by ATRA is an important process for achieving an effective response in treatment of leukemia. Tretinoin cyclin dependent kinase 1 Homo sapiens
5 In addition, expression of wee1 kinase and Cdc25A/C phosphatases also coincide with CDK1 expression and its subcellular localization in response to ATRA treatment. Tretinoin cyclin dependent kinase 1 Homo sapiens
6 Our study reveals a novel mechanism by which CDK1 and RARgamma coordinate with ATRA to influence cell cycle progression and cellular differentiation. Tretinoin cyclin dependent kinase 1 Homo sapiens