Title : Knockdown of DEPTOR induces apoptosis, increases chemosensitivity to doxorubicin and suppresses autophagy in RPMI-8226 human multiple myeloma cells in vitro.

Pub. Date : 2013 May

PMID : 23503641






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Knockdown of DEPTOR induces apoptosis, increases chemosensitivity to doxorubicin and suppresses autophagy in RPMI-8226 human multiple myeloma cells in vitro. Doxorubicin DEP domain containing MTOR interacting protein Homo sapiens
2 The downregulation of DEPTOR inhibited proliferation, enhanced the doxorubicin-induced growth inhibitory effects on RPMI-8226 cells, and increased the expression of cleaved caspase-3 and cleaved poly(ADP-ribose) polymerase (PARP). Doxorubicin DEP domain containing MTOR interacting protein Homo sapiens
3 In conclusion, our data demonstrated that the downregulation of DEPTOR induces apoptosis, increases chemosensitivity to doxorubicin, and suppresses autophagy and the activation of the PI3K/Akt signaling pathway in RPMI-8226 human multiple myeloma cells. Doxorubicin DEP domain containing MTOR interacting protein Homo sapiens