Title : EGFR-TKI resistance due to BIM polymorphism can be circumvented in combination with HDAC inhibition.

Pub. Date : 2013 Apr 15

PMID : 23382048






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 BIM upregulation is required for apoptosis induction by EGF receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKI) in EGFR-mutant forms of non-small cell lung cancer (NSCLC). bim epidermal growth factor receptor Homo sapiens
2 BIM upregulation is required for apoptosis induction by EGF receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKI) in EGFR-mutant forms of non-small cell lung cancer (NSCLC). bim epidermal growth factor receptor Homo sapiens
3 BIM upregulation is required for apoptosis induction by EGF receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKI) in EGFR-mutant forms of non-small cell lung cancer (NSCLC). bim epidermal growth factor receptor Homo sapiens
4 BIM upregulation is required for apoptosis induction by EGF receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKI) in EGFR-mutant forms of non-small cell lung cancer (NSCLC). bim epidermal growth factor receptor Homo sapiens