Pub. Date : 2013 Mar
PMID : 23345593
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux. | Copper | synthesis of cytochrome C oxidase 1 | Homo sapiens |
| 2 | SCO1 and SCO2 are metallochaperones whose principal function is to add two copper ions to the catalytic core of cytochrome c oxidase (COX). | Copper | synthesis of cytochrome C oxidase 1 | Homo sapiens |
| 3 | However, affected tissues of SCO1 and SCO2 patients exhibit a combined deficiency in COX activity and total copper content, suggesting additional roles for these proteins in the regulation of cellular copper homeostasis. | Copper | synthesis of cytochrome C oxidase 1 | Homo sapiens |
| 4 | However, affected tissues of SCO1 and SCO2 patients exhibit a combined deficiency in COX activity and total copper content, suggesting additional roles for these proteins in the regulation of cellular copper homeostasis. | Copper | synthesis of cytochrome C oxidase 1 | Homo sapiens |
| 5 | Here we show that both the redox state of the copper-binding cysteines of SCO1 and the abundance of SCO2 correlate with cellular copper content and that these relationships are perturbed by mutations in SCO1 or SCO2, producing a state of apparent copper overload. | Copper | synthesis of cytochrome C oxidase 1 | Homo sapiens |
| 6 | Here we show that both the redox state of the copper-binding cysteines of SCO1 and the abundance of SCO2 correlate with cellular copper content and that these relationships are perturbed by mutations in SCO1 or SCO2, producing a state of apparent copper overload. | Copper | synthesis of cytochrome C oxidase 1 | Homo sapiens |
| 7 | Here we show that both the redox state of the copper-binding cysteines of SCO1 and the abundance of SCO2 correlate with cellular copper content and that these relationships are perturbed by mutations in SCO1 or SCO2, producing a state of apparent copper overload. | Copper | synthesis of cytochrome C oxidase 1 | Homo sapiens |
| 8 | Here we show that both the redox state of the copper-binding cysteines of SCO1 and the abundance of SCO2 correlate with cellular copper content and that these relationships are perturbed by mutations in SCO1 or SCO2, producing a state of apparent copper overload. | Copper | synthesis of cytochrome C oxidase 1 | Homo sapiens |
| 9 | Here we show that both the redox state of the copper-binding cysteines of SCO1 and the abundance of SCO2 correlate with cellular copper content and that these relationships are perturbed by mutations in SCO1 or SCO2, producing a state of apparent copper overload. | Copper | synthesis of cytochrome C oxidase 1 | Homo sapiens |
| 10 | Here we show that both the redox state of the copper-binding cysteines of SCO1 and the abundance of SCO2 correlate with cellular copper content and that these relationships are perturbed by mutations in SCO1 or SCO2, producing a state of apparent copper overload. | Copper | synthesis of cytochrome C oxidase 1 | Homo sapiens |
| 11 | These results demonstrate that COX19 is necessary for the transduction of a SCO1-dependent mitochondrial redox signal that regulates ATP7A-mediated cellular copper efflux. | Copper | synthesis of cytochrome C oxidase 1 | Homo sapiens |