Title : Transgenerational inheritance of increased fat depot size, stem cell reprogramming, and hepatic steatosis elicited by prenatal exposure to the obesogen tributyltin in mice.

Pub. Date : 2013 Mar

PMID : 23322813






2 Functional Relationships(s)
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1 BACKGROUND: We have previously shown that exposure to tributyltin (TBT) modulates critical steps of adipogenesis through RXR/PPARgamma and that prenatal TBT exposure predisposes multipotent mesenchymal stem cells (MSCs) to become adipocytes by epigenetic imprinting into the memory of the MSC compartment. tributyltin peroxisome proliferator activated receptor gamma Mus musculus
2 BACKGROUND: We have previously shown that exposure to tributyltin (TBT) modulates critical steps of adipogenesis through RXR/PPARgamma and that prenatal TBT exposure predisposes multipotent mesenchymal stem cells (MSCs) to become adipocytes by epigenetic imprinting into the memory of the MSC compartment. tributyltin peroxisome proliferator activated receptor gamma Mus musculus