Title : Chemical synthesis, docking studies and biological effects of a pan peroxisome proliferator-activated receptor agonist and cyclooxygenase inhibitor.

Pub. Date : 2013 Mar 12

PMID : 23305993






1 Functional Relationships(s)
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1 The agonist action on PPARgamma was also observed by a pharmacological approach, as the reduction in the Escherichia coli lipopolysaccharide (LPS)-induced interleukin 1 beta (IL-1beta) secretion and nitric oxide (NO) production by mouse neutrophils was blocked by GW9962, a specific PPARgamma antagonist. Nitric Oxide peroxisome proliferator activated receptor gamma Mus musculus