Title : A novel melanocortin-4 receptor mutation MC4R-P272L associated with severe obesity has increased propensity to be ubiquitinated in the ER in the face of correct folding.

Pub. Date : 2012

PMID : 23251400






1 Functional Relationships(s)
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1 When expressed in neuronal cells, the cell surface abundance of wild-type MC4R and of the N74I and I251L variants and the cAMP generated by these receptors in response to exposure to the agonist, alpha-MSH, were not different. Cyclic AMP proopiomelanocortin Homo sapiens