Title : Modulation of multidrug resistance in cancer cells by chelidonine and Chelidonium majus alkaloids.

Pub. Date : 2013 Feb 15

PMID : 23238299






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA. Alkaloids ATP binding cassette subfamily B member 1 Homo sapiens