Title : Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interaction.

Pub. Date : 2012 Dec 6

PMID : 23216755






1 Functional Relationships(s)
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1 Using western blot analysis and apoptosis assays of cultured cells, we found that the overexpression of Hsp70 by transfection or the activation of Hsp70 by geldanamycin selectively mediated the degradation of cytosolic PrPs and restored cytosolic PrP-induced cytotoxicity. geldanamycin caspase recruitment domain family member 14 Homo sapiens