Title : Human anti-Aβ IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide.

Pub. Date : 2012

PMID : 23209707






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Previously, we and others have shown that natural human IgGs (NAbs) target diverse Abeta conformers and have therapeutic potential. nabs amyloid beta precursor protein Homo sapiens
2 Importantly, NAbs also recognized Abeta extracted from the water-soluble phase of human AD brain, including species that migrated on denaturing PAGE as SDS-stable dimers. nabs amyloid beta precursor protein Homo sapiens
3 The antibody"s lack of reactivity against a linear sequence epitope was confirmed by our ability to isolate anti-Abeta NAbs from intravenous immunoglobulin using affinity matrices, immunoglobulin light chain fibrils and Cibacron blue, which had no sequence similarity with the peptide. nabs amyloid beta precursor protein Homo sapiens
4 These findings suggest that further investigations on the molecular basis and the therapeutic/diagnostic potential of anti-Abeta NAbs are warranted. nabs amyloid beta precursor protein Homo sapiens