Title : Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.

Pub. Date : 2013 Apr

PMID : 23172919






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. NAD CD38 antigen Mus musculus
2 Moreover, CD38 knockout mice have higher NAD(+) levels and are protected against obesity and metabolic syndrome. NAD CD38 antigen Mus musculus
3 Here, we show that CD38 regulates global protein acetylation through changes in NAD(+) levels and sirtuin activity. NAD CD38 antigen Mus musculus
4 We show that pharmacological inhibition of CD38 results in higher intracellular NAD(+) levels and that treatment of cell cultures with apigenin decreases global acetylation as well as the acetylation of p53 and RelA-p65. NAD CD38 antigen Mus musculus
5 Our results show that CD38 is a novel pharmacological target to treat metabolic diseases via NAD(+)-dependent pathways. NAD CD38 antigen Mus musculus