Title : Nitric oxide and superoxide mediate diesel particle effects in cytokine-treated mice and murine lung epithelial cells--implications for susceptibility to traffic-related air pollution.

Pub. Date : 2012 Nov 15

PMID : 23151036






2 Functional Relationships(s)
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1 DEP effects were mediated by: (1) increased ROS including superoxide anion (O(2)( -)), related to increased xanthine dehydrogenase expression and reduced cytosolic superoxide dismutase activity; and (2) increased peroxynitrite generation related to interaction of O(2)( -) with cytokine-induced NO. Superoxides xanthine dehydrogenase Mus musculus
2 DEP effects were mediated by: (1) increased ROS including superoxide anion (O(2)( -)), related to increased xanthine dehydrogenase expression and reduced cytosolic superoxide dismutase activity; and (2) increased peroxynitrite generation related to interaction of O(2)( -) with cytokine-induced NO. Superoxides xanthine dehydrogenase Mus musculus