Title : Activation of haem-oxidized soluble guanylyl cyclase with BAY 60-2770 in human platelets lead to overstimulation of the cyclic GMP signaling pathway.

Pub. Date : 2012

PMID : 23144808






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 RESULTS: BAY 60-2770 (0.001-10 microM) produced significant inhibition of collagen (2 microg/ml)- and thrombin (0.1 U/ml)-induced platelet aggregation that was markedly potentiated by the sGC inhibitor ODQ (10 microM). 1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one coagulation factor II, thrombin Homo sapiens
2 Collagen- and thrombin-induced alpha(IIb)beta(3) activation was markedly inhibited by BAY 60-2770 that was further inhibited by ODQ. 1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one coagulation factor II, thrombin Homo sapiens