Title : Regulation of endothelial nitric-oxide synthase (NOS) S-glutathionylation by neuronal NOS: evidence of a functional interaction between myocardial constitutive NOS isoforms.

Pub. Date : 2012 Dec 21

PMID : 23091050






3 Functional Relationships(s)
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1 Although inhibitors of xanthine oxidoreductase (XOR) or NOX2 NADPH oxidase caused a similar reduction in myocardial O(2)( -), only XOR inhibition reduced eNOS S-glutathionylation and Ser-1177 phosphorylation and restored both eNOS coupled activity and the negative inotropic and [Ca(2+)](i) transient response to beta(3)-AR stimulation in nNOS(-/-) mice. Superoxides xanthine dehydrogenase Mus musculus
2 Although inhibitors of xanthine oxidoreductase (XOR) or NOX2 NADPH oxidase caused a similar reduction in myocardial O(2)( -), only XOR inhibition reduced eNOS S-glutathionylation and Ser-1177 phosphorylation and restored both eNOS coupled activity and the negative inotropic and [Ca(2+)](i) transient response to beta(3)-AR stimulation in nNOS(-/-) mice. Superoxides xanthine dehydrogenase Mus musculus
3 In summary, our data show that increased O(2)( -) production by XOR selectively uncouples eNOS activity and abolishes the negative inotropic effect of beta(3)-AR stimulation in nNOS(-/-) myocytes. Superoxides xanthine dehydrogenase Mus musculus