Title : Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2.

Pub. Date : 2012 Oct 18

PMID : 23079185






1 Functional Relationships(s)
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1 In human endothelial cells, TNFalpha induced superoxide production, p-selectin, tissue factor and PAI-1, and suppressed thrombomodulin, resulting in an accelerated endothelial dependent blood clotting in vitro. Superoxides tumor necrosis factor Homo sapiens