Title : TNF-α induces endothelial dysfunction via PKC-ζ-dependent NADPH oxidase activation.

Pub. Date : 2012 Oct

PMID : 23073791






3 Functional Relationships(s)
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1 In vitro superoxide generation in HAECs was detected by DHE staining after administration of TNF-alpha. Superoxides tumor necrosis factor Mus musculus
2 In vitro TNF-alpha increased superoxide production and p47(phox) expression in HAECs, and such increases could be ameliorated by the specific PKC-zeta inhibitor. Superoxides tumor necrosis factor Mus musculus
3 Our findings suggest that superoxide over-production triggered by PKC-zeta-dependent NADPH oxidase activation contributes to TNF-alpha-induced endothelial dysfunction. Superoxides tumor necrosis factor Mus musculus