Title : PPARĪ±-Independent Arterial Smooth Muscle Relaxant Effects of PPARĪ± Agonists.

Pub. Date : 2012

PMID : 23008696






3 Functional Relationships(s)
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1 The PPARalpha agonists GW7647, WY14643, and gemfibrozil acutely relaxed aortas held under isometric tension and dilated pressurized MCAs with the following order of potency: GW7647>>WY14643>gemfibrozil. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus
2 The PPARalpha agonists GW7647, WY14643, and gemfibrozil acutely relaxed aortas held under isometric tension and dilated pressurized MCAs with the following order of potency: GW7647>>WY14643>gemfibrozil. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus
3 In aortas, GW7647 and WY14643 elevated cGMP levels by stimulating soluble guanylyl cyclase (sGC), and inhibition of sGC with ODQ blunted relaxations to PPARalpha agonists. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus