Title : Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses.

Pub. Date : 2012 Sep 21

PMID : 22999953






1 Functional Relationships(s)
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1 These findings establish that CYP7B1 and HSD3B7, as well as CH25H, have essential roles in controlling oxysterol production in lymphoid tissues, and they suggest that differential enzyme expression in stromal cell subsets establishes 7alpha,25-OHC gradients required for B cell responses. Oxysterols hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Homo sapiens