Title : Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.

Pub. Date : 2012 Oct 1

PMID : 22939697






1 Functional Relationships(s)
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1 An in vitro assay identified the p-methoxy phenyl ureido thiobutyric acid derivative KSM-01 (IC(50)=0.28+-0.09nM) having a higher affinity to activate PPAR-alpha than the PPAR-alpha agonist GW7647 (IC(50)=0.46+-0.19nM). GW 7647 peroxisome proliferator activated receptor alpha Mus musculus