Title : NF-κB-dependent IL-8 induction by prostaglandin E(2) receptors EP(1) and EP(4).

Pub. Date : 2013 Feb

PMID : 22924768






3 Functional Relationships(s)
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1 In HEK-EP(1) + EP(4) cells, PGE(2) -mediated IL-8 promoter activation and IL-8 mRNA induction were blunted by inhibition of IkappaB kinase. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
2 CONCLUSIONS AND IMPLICATIONS: These findings suggest that PGE(2) -mediated NF-kappaB activation by simultaneous stimulation of EP(1) and EP(4) receptors induces maximal IL-8 promoter activation and IL-8 mRNA and protein induction. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
3 CONCLUSIONS AND IMPLICATIONS: These findings suggest that PGE(2) -mediated NF-kappaB activation by simultaneous stimulation of EP(1) and EP(4) receptors induces maximal IL-8 promoter activation and IL-8 mRNA and protein induction. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens